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KMID : 1040620160220040495
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Clinical and Molecular Hepatology
2016 Volume.22 No. 4 p.495 ~ p.498
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A case of levocetirizine-induced liver injury
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Jung Moon-Chan
Kim Ja-Kyung
Cho Jae-Yeon
Song Jae-Won
Lee Bo-Hyun
Park Ji-Won
Seo Jin-Won
Kim Sung-Eun
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Abstract
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Levocetirizine is a second-generation nonsedative antihistaminic agent that has been demonstrated to be safe and effective for treating allergic disease. There was only one case report of levocetirizine-induced liver toxicity, but a liver biopsy was not performed. In this article, we present the first case of levocetirizine-induced liver injury with histologic findings. A 48-year-old man was hospitalized with jaundice and generalized pruritus that had developed after 2 months of therapy with levocetirizine for prurigo nodularis. Laboratory findings revealed acute hepatitis with cholestasis. A liver biopsy demonstrated portal inflammation and hepatitis with apoptotic hepatocytes. The patient fully recovered 3 weeks after withdrawing levocetirizine. Although levocetirizine is safe and effective, physicians should be aware of its potential hepatotoxicity.
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KEYWORD
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Hepatotoxicity, Levocetirizine, Cholestasis
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